Analisis Senyawa Metabolit Sekunder Ekstrak Metanol Kulit Batang Lino (Grewia koordersiana, Burret) dengan UPLC-QToF-MS/MS

WOKAL, Monika Woli (2025) Analisis Senyawa Metabolit Sekunder Ekstrak Metanol Kulit Batang Lino (Grewia koordersiana, Burret) dengan UPLC-QToF-MS/MS. Undergraduate thesis, Universitas Katolik Widya Mandira.

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Abstract

Grewia koordersiana, Burret is a traditional medicinal plant widely used by the people of East Nusa Tenggara and is effective for treating various diseases, including liver, ulcers and wounds. This study aims to identify the types of secondary metabolite compounds in the methanol extract of the bark of G. koordersiana, Burret. The research method used is maceration extraction with methanol solvent. Analysis of compound content using Ultra Performance Liquid Chromatography-Quadrupole-Time-of-Flight–Mass Spectrometry (UPLC-QToF- MS/MS). The extraction results obtained are thick, paste-like extracts and red in color. Analysis of compound content obtained major compounds in five main groups of secondary metabolites, namely: 6-hydroxy-5-[(2S,3R,4S,5S,6R)- trihydroxyoxanyl]oxyfurochromen-2-one (flavonoid), acetophenone (phenolic), 2- [[1-[[6-(4-Cyanophenoxy)-3-pyridinyl]methyl]-4-hydroxy-6-oxo-2,3- dihydropyridine-5-carbonyl]amino]acetic acid (alkaloid),(3S,8R,9S,10R,13S,14S,17S)-13-methyl-cyclopenta[a]phenanthrene-3,17-diol (steroid), and Trans-(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-ethyl-6- methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4- ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol (terpenoid). It was concluded that the analyzed sample contained bioactive compounds from the flavonoid, alkaloid, phenolic, terpenoid, and steroid groups.

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